What makes Boston unique for startups?

Biotech. Boston/Cambridge is the undisputed global center of biotech and life sciences startups. If you are building a biotech, pharma, or health science company, there is no better place. The city is also strong in enterprise software, robotics, and edtech thanks to MIT and Harvard.

Massachusetts

How to Start a Business in Boston

Boston is one of the strongest startup ecosystems in the US, powered by MIT, Harvard, and a deep bench of research universities. The city is the global leader in biotech and life sciences, and has significant strength in enterprise software, robotics, and edtech.

Startup ecosystem

Boston/Cambridge is anchored by Kendall Square (often called "the most innovative square mile on earth"), home to MIT, numerous biotech companies, and major VCs like General Catalyst, Battery Ventures, and Bessemer. The Route 128 corridor extends the tech ecosystem into the suburbs.

Key industries

- Biotech and life sciences

- Robotics and hardware

- Enterprise software

- Edtech

- Financial services

- Cybersecurity

Resources for founders

- MassChallenge - one of the largest accelerators in the world (no equity)

- Techstars Boston

- Cambridge Innovation Center (CIC)

- MIT Enterprise Forum

- Massachusetts Small Business Development Center

Cost of living

High. Average rent for a 1-bedroom is $2,500-$3,200/month. Massachusetts has state income tax. However, the concentration of universities means strong intern and junior talent pipelines.

Business regulations

Massachusetts has moderate business regulations. LLC formation through the Secretary of the Commonwealth. The state has strong employee protection laws and specific requirements for biotech and healthcare companies. Boston has local business licensing requirements.